The best Side of ceesdekker

The best Side of ceesdekker

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‘Yes, that is definitely about right. I seek out a Actual physical knowledge of Organic units inside a base-up way. I do think you can distinguish 3 strains of research in my group at this time. The very first worries chromosome structure: How would you have a metre-long DNA polymer folded and organised in such a microscopic cell? We now have made visualisation methods that enable us to review how, for example, SMC proteins loop DNA (video clip on Youtube) in an effort to Make up chromosomes.

Our team reports bacterial cell division and is aiming to represent a ‘base up biology’ in synthetic cells that can autonomously divide. Our primary interest lies in mobile division, chromatin framework, and spatial Handle.

The subsequent article content are merged in Scholar. Their combined citations are counted only for the initial report.

Nanofabrication of electrodes with sub-five nm spacing for transport experiments on solitary molecules and metallic clusters

2015, discovery that condensin can be a extremely adaptable protein framework; and initial detection of DNA knots applying nanopores

The coiled-coil in the human Rad50 DNA repair protein incorporates distinct segments of elevated adaptability

We shape bacteria into sorts that deviate from their pure phenotype. Specially, I will present our ability to condition Stay E. coli microorganisms into novel shapes such ceesdekker as rectangles, squares, triangles and circles.

Dynamic ParB–DNA interactions initiate and preserve a partition condensate for bacterial chromosome segregation

‘Certainly, I realize people today have been astonished at time. At the conclusion of the nineties, After i was in my forties, I was Professor of Molecular Electronics and I've to confess that it had become a little bit bored, I didn’t learn Considerably anymore. The field went a lot more into the applying side, how you may combine nanotubes into Digital circuits.

Resolving the phase measurement in condensin-driven DNA loop extrusion identifies ATP binding because the stage-producing procedure

An integrated microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes

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2013, managed shaping of live bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations within the handedness of histone tetrasomes